Fast inactivation of Shal (Kv4) K+ channels is regulated by the novel interactor SKIP3 in Drosophila neurons
نویسندگان
چکیده
منابع مشابه
Shal/Kv4 Channels Are Required for Maintaining Excitability during Repetitive Firing and Normal Locomotion in Drosophila
BACKGROUND Rhythmic behaviors, such as walking and breathing, involve the coordinated activity of central pattern generators in the CNS, sensory feedback from the PNS, to motoneuron output to muscles. Unraveling the intrinsic electrical properties of these cellular components is essential to understanding this coordinated activity. Here, we examine the significance of the transient A-type K(+) ...
متن کاملA novel subunit for shal K+ channels radically alters activation and inactivation.
Shal (Kv4) potassium channel genes encode classical subthreshold A-currents, and their regulation may be a key factor in determining neuronal firing frequency. The inactivation rate of Shal channels is increased by a presently unidentified class of proteins in both Drosophila and mammals. We have cloned a novel Shal channel subunit (jShalgamma1) from the jellyfish Polyorchis penicillatus that a...
متن کاملInhibition of the Kv4 (Shal) family of transient K+ currents by arachidonic acid.
We have found that transient A-type currents expressed in Xenopus oocytes from members of the Kv4 family are suppressed by arachidonic acid. Currents from members of the Kv1, Kv2, and Kv3 families showed little or no inhibition by fatty acids in this expression system, although Shaker currents showed a modest increase in peak amplitude. The inhibition of Kv4 channels was not prevented by cyclo-...
متن کاملTraffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway
The traffic of Kv4 K+ channels is regulated by the potassium channel interacting proteins (KChIPs). Kv4.2 expressed alone was not retained within the ER, but reached the Golgi complex. Coexpression of KChIP1 resulted in traffic of the channel to the plasma membrane, and traffic was abolished when mutations were introduced into the EF-hands with channel captured on vesicular structures that colo...
متن کاملElimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.
The Kv4 A-type potassium currents contribute to controlling the frequency of slow repetitive firing and back-propagation of action potentials in neurons and shape the action potential in heart. Kv4 currents exhibit rapid activation and inactivation and are specifically modulated by K-channel interacting proteins (KChIPs). Here we report the discovery and functional characterization of a modular...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2009
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2009.05.003